Chan Zuckerberg Initiative: Challenge Grants in Visual Proteomics

The Chan Zuckerberg Initiative (CZI) has issued a Request for Applications for challenge grants in the field of Visual Proteomics.

The ability to view protein molecules in cells and monitor changes in their structure, quantity, distribution, and interactions is key to understanding what causes diseases and finding treatments and cures. The long-term goal of the RFA is to drive technology development aimed at visualizing proteins and their interactions inside the cell. The particular funding opportunity is explicitly aimed at technology development and is not intended to support question-driven basic or translational research, clinical trials, or drug development. Preliminary data is encouraged but not required.

Examples of research themes include but are not limited to hardware and software development designed to enhance contrast and resolution for electron tomography, high-resolution correlated light and electron microscopy (CLEM), and FIB-SEM; sample preparation improvements for electron tomography, or high-resolution correlated light and electron microscopy (CLEM) approaches, and FIB-SEM; software development or development of new computational techniques and algorithms for identifying protein molecules inside cells or segmenting cellular sub-structures.

CZI particularly encourage applications from researchers in disciplines outside of biomedicine who bring new technology, resources, or frameworks to studying proteins and their interactions inside of cells; women, underrepresented minorities, and members of underserved populations; and early-career investigators, defined as principal investigators who have been in an independent faculty role for less than six years at the time of application.

Successful outcomes for the RFA include development of hardware and software that will enhance contrast and resolution; development of hardware, software, or methods that will improve sample preparation; and development of new computational techniques and algorithms for identifying protein molecules inside cells.

CZI seeks investigators who will contribute to a collaborative interdisciplinary network and the advancement of the visual proteomics field.  Awards will be thirty months in duration, with a start date of no earlier than August 1, 2021. (Actual start dates may vary.)

For the complete RFA, including application requirements and instructions, see the Chan Zuckerberg Initiative website.