Patient-Centered Outcomes Research Institute: Optimizing Infrastructure for Conducting Patient-Centered Outcomes Research

PCORnet®, the National Patient-Centered Clinical Research Network is intended to serve as a national resource for conducting rapid, efficient, patient-centered observational and interventional randomized research that improves healthcare delivery and health outcomes.

This announcement describes the scope of work for PCORnet Clinical Research Networks (CRNs) for Phase 3 and available funding to allow for Phase 3’s execution. CRNs are system-based networks that include hospitals and community based-practices, and that may include health plans, all of which routinely and securely collect individual patient-level data. A list of currently funded PCORnet Network Partners can be found at

In Phase 3 of PCORnet, CRNs will ensure the continuity and optimization of critical CRN resources and operations developed in prior phases to facilitate implementation of definitive research studies that are national in scope. Phase 3 will focus on optimizing infrastructure to increase diversity of populations and care settings, efficiently implement research studies addressing PCORI’s Strategic Research Priorities, strengthen patient and stakeholder engagement, and deliver high-fidelity, high integrity data.