Patient-Centered Outcomes Research Institute (PCORI): Multiple Opportunities

Broad PCORI Funding Announcements — Cycle 1 2021
The Broad PCORI Funding Announcements (PFAs) seek investigator-initiated applications for patient-centered comparative clinical effectiveness research (CER) projects aligned with our priority areas for research. This PFA covers the following four priority areas outlined in PCORI’s National Priorities for Research and Research Agenda: Addressing Disparities; Assessment of Prevention, Diagnosis, and Treatment Options; Communication and Dissemination Research, and Improving Healthcare Systems. These broad areas encompass the patient-centered comparative CER we support.
Amount: Addressing Disparities; Assessment of Prevention, Diagnosis, and Treatment Options; and Improving Healthcare Systems: up to $3 million (Small) – up to $5 million (Large) — Communication & Dissemination Research: up to $2 million
Link to Complete RFP

Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes — Cycle 1
The Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes PFA emphasizes relevant Methodology Standards and the PCORI Guidance on the Design and Conduct of Trials in Real-World Settings. PCORI seeks to fund clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; or eliminating health or healthcare disparities. Randomized study designs are strongly encouraged but not required.
Amount: Up to $10 Million
Link to Complete RFP

Improving Methods for Conducting Patient-Centered Outcomes Research — Cycle 1 2021
PCORI aims to fund studies that address high-priority methodological gaps in patient-centered outcomes research (PCOR) and clinical comparative effectiveness research (CER). PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by PCOR/CER studies. For the Cycle 1 2021 Methods PFA, PCORI has identified the following areas as programmatic priorities:
– Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research
– Methods to Improve Study Design
– Methods to Support Data Research Networks
– Methods Related to Ethical and Human Subjects Protections Issues in PCOR/CER
Amount: $750,000
Link to Complete RFP